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| First Basemen Single-Season On-Base Pct Leaderboard | |
| * - Indicates Hall of Fame
+ - indicates hit-less at-bats added to meet 502PA requirement. |
| Rank | Player | On-Base Pct | PA | Year | Career Leaderboard |
| 1. | Hank Hulvey | .4925 | 681 | 1924 | |
| 2. | Hank Hulvey | .4888 | 711 | 1925 | |
| 3. | Hank Hulvey | .4854 | 663 | 1929 | |
| 4. | Hank Hulvey | .4724 | 682 | 1926 | |
| 5. | Hank Hulvey | .4532 | 635 | 1928 | |
| 6. | Hank Hulvey | .4517 | 594 | 1927 | |
| 7. | Tim Jordan | .4341 | 539 | 1912 | |
| 8. | Dan McGann | .4281 | 605 | 1903 | |
| 9. | Harry Hooper * | .4246 | 643 | 1913 | |
| 10. | Joe Judge | .4237 | 532 | 1921 | |
| 11. | Jack Fournier | .4228 | 620 | 1918 | |
| 12. | Tim Jordan | .4208 | 610 | 1909 | |
| 13. | Tim Jordan | .4205 | 620 | 1907 | |
| 14. | Harry Hooper * | .4193 | 602 | 1911 | |
| 15. | Lou Gehrig | .4178 | 639 | 1929 | |
| 16. | Tim Jordan | .4162 | 581 | 1915 | |
| 17. | Harry Hooper * | .4146 | 644 | 1916 | |
| 18. | George Sisler | .4144 | 654 | 1925 | |
| 19. | Buck Freeman | .4122 | 575 | 1901 | |
| 20. | Lou Gehrig | .4099 | 584 | 1924 | |
| 21. | Stuffy McInnis | .4079 | 630 | 1912 | |
| 22. | Harry Hooper * | .4068 | 591 | 1922 | |
| 23. | Cy Seymour | .4066 | 576 | 1903 | |
| 24. | Lou Gehrig | .4066 | 637 | 1925 | |
| 25. | George Carr | .4044 | 675 | 1923 | |
| 26. | Harry Hooper * | .4042 | 668 | 1914 | |
| 27. | George Grantham | .4039 | 620 | 1926 | |
| 28. | Jimmy Hudgens | .4028 | 576 | 1928 | |
| 29. | Jack Fournier | .4020 | 607 | 1915 | |
| 30. | Frank Isbell | .4017 | 597 | 1903 | |
| 31. | Jake Daubert | .4004+ | 485 | 1911 | |
| 32. | Dave Bancroft | .4000 | 507 | 1923 | |
| Tim Jordan | .4000 | 635 | 1910 | ||
| Joe Kelley | .4000 | 605 | 1903 | ||
| 35. | Joe Judge | .3993 | 615 | 1920 | |
| 36. | Jimmy Hudgens | .3990 | 599 | 1927 | |
| 37. | Buck Freeman | .3986 | 592 | 1903 | |
| 38. | Joe Judge | .3984+ | 497 | 1922 | |
| Tim Jordan | .3984+ | 498 | 1913 | ||
| 40. | Jack Fournier | .3980 | 510 | 1921 | |
| 41. | Paul Waner | .3967 | 608 | 1929 | |
| 42. | Dick Hoblitzel | .3948 | 505 | 1912 | |
| 43. | Mike Grady | .3947 | 604 | 1903 | |
| 44. | Joe Kelley | .3939 | 657 | 1904 | |
| 45. | Paul Waner | .3938 | 616 | 1927 | |
| 46. | Tim Jordan | .3937 | 635 | 1914 | |
| 47. | George Grantham | .3936 | 593 | 1928 | |
| 48. | George Sisler | .3934 | 633 | 1920 | |
| 49. | Bill Mellor | .3931 | 613 | 1904 | |
| 50. | Harry Hooper * | .3912 | 525 | 1921 | |
| 51. | Joe Judge | .3903 | 548 | 1919 | |
| 52. | Tim Jordan | .3899 | 638 | 1911 | |
| 53. | John Anderson | .3889 | 558 | 1901 | |
| 54. | Harry Hooper * | .3884 | 636 | 1917 | |
| 55. | George Sisler | .3883 | 615 | 1921 | |
| 56. | George Grantham | .3880 | 587 | 1923 | |
| 57. | George Sisler | .3878 | 655 | 1922 | |
| 58. | Jack Fournier | .3872 | 594 | 1920 | |
| 59. | Harry Hooper * | .3872 | 515 | 1919 | |
| 60. | Joe Kelley | .3870 | 635 | 1905 | |
| 61. | Lou Gehrig | .3870 | 646 | 1928 | |
| 62. | Del Bissonette | .3859 | 583 | 1929 | |
| 63. | Jim Bottomley | .3854 | 649 | 1923 | |
| 64. | Jack Fournier | .3847 | 590 | 1916 | |
| 65. | Jimmy Hudgens | .3841 | 591 | 1926 | |
| 66. | Lu Blue | .3839 | 564 | 1924 | |
| 67. | Lou Gehrig | .3838 | 628 | 1926 | |
| 68. | Bill Kelly | .3836 | 611 | 1926 | |
| 69. | Harry Hooper * | .3832 | 608 | 1910 | |
| 70. | Tim Jordan | .3831 | 600 | 1906 | |
| 71. | Fred Luderus | .3830 | 624 | 1913 | |
| 72. | Josh Devore | .3829 | 639 | 1920 | |
| 73. | Buck Leonard | .3826 | 612 | 1928 | |
| 74. | George Grantham | .3825 | 617 | 1927 | |
| 75. | Dave Bancroft | .3822 | 530 | 1924 | |
| 76. | Tim Jordan | .3821 | 655 | 1908 | |
| 77. | Fred Luderus | .3820 | 623 | 1912 | |
| 78. | George Grantham | .3816 | 610 | 1925 | |
| 79. | George Sisler | .3813 | 634 | 1917 | |
| 80. | Jack Fournier | .3813 | 536 | 1923 | |
| 81. | Yam Yaryan | .3803 | 548 | 1922 | |
| 82. | George Grantham | .3798 | 595 | 1924 | |
| 83. | Ivy Griffin | .3795 | 585 | 1923 | |
| 84. | George Carr | .3789 | 570 | 1927 | |
| 85. | Jimmy Hudgens | .3785+ | 472 | 1923 | |
| 86. | Jim Bottomley | .3785 | 652 | 1924 | |
| 87. | Jake Beckley | .3783 | 601 | 1903 | |
| 88. | Jim Bottomley | .3783 | 649 | 1922 | |
| 89. | Dale Alexander | .3780 | 626 | 1929 | |
| 90. | Jimmy Hudgens | .3775 | 506 | 1924 | |
| 91. | Jack Fournier | .3765+ | 490 | 1919 | |
| 92. | Russ Wrightstone | .3763 | 574 | 1920 | |
| 93. | John Anderson | .3760 | 602 | 1903 | |
| 94. | Kitty Bransfield | .3755 | 522 | 1903 | |
| 95. | Bill Kelly | .3746 | 638 | 1925 | |
| 96. | Bill Terry | .3745+ | 487 | 1929 | |
| Jimmy O'Connell | .3745+ | 485 | 1925 | ||
| 98. | Jack Fournier | .3743 | 555 | 1912 | |
| 99. | George Grantham | .3729 | 584 | 1929 | |
| 100. | Joe Kelley | .3725 | 561 | 1902 |
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