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| First Basemen Single-Season RBIs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | RBIs | PA | Year | Career Leaderboard |
| 1. | Harry Davis | 132 | 647 | 1904 | |
| 2. | Bill Kelly | 127 | 638 | 1925 | |
| 3. | Bill Kelly | 125 | 648 | 1924 | |
| 4. | Harry Hooper * | 121 | 668 | 1914 | |
| Harry Davis | 121 | 680 | 1905 | ||
| 6. | Lou Gehrig | 118 | 637 | 1925 | |
| Harry Hooper * | 118 | 643 | 1913 | ||
| John Anderson | 118 | 558 | 1901 | ||
| 9. | George Sisler | 115 | 615 | 1921 | |
| John Anderson | 115 | 602 | 1903 | ||
| 11. | Jim Bottomley | 114 | 649 | 1923 | |
| Harry Hooper * | 114 | 644 | 1916 | ||
| 13. | Lou Gehrig | 112 | 639 | 1929 | |
| Snake Henry | 112 | 592 | 1925 | ||
| George Sisler | 112 | 633 | 1920 | ||
| 16. | Bill Kelly | 111 | 633 | 1923 | |
| 17. | Lou Gehrig | 109 | 628 | 1926 | |
| Cy Seymour | 109 | 576 | 1903 | ||
| 19. | Hal Chase | 108 | 607 | 1912 | |
| Joe Kelley | 108 | 605 | 1903 | ||
| 21. | Bill Terry | 107 | 629 | 1925 | |
| 22. | Hal Chase | 106 | 617 | 1913 | |
| Buck Freeman | 106 | 575 | 1901 | ||
| 24. | Bill Kelly | 105 | 613 | 1927 | |
| Harry Hooper * | 105 | 602 | 1911 | ||
| 26. | Bill Kelly | 104 | 627 | 1928 | |
| George Sisler | 104 | 654 | 1925 | ||
| 28. | Buck Freeman | 103 | 592 | 1903 | |
| 29. | Hal Chase | 102 | 602 | 1914 | |
| 30. | Bill Kelly | 101 | 625 | 1929 | |
| Paul Waner | 101 | 616 | 1927 | ||
| Fred Luderus | 101 | 627 | 1914 | ||
| Buck Freeman | 101 | 636 | 1904 | ||
| Bill Mellor | 101 | 613 | 1904 | ||
| 35. | Earl Webb | 100 | 578 | 1925 | |
| Lou Gehrig | 100 | 584 | 1924 | ||
| Russ Wrightstone | 100 | 575 | 1921 | ||
| 38. | Jim Bottomley | 98 | 652 | 1924 | |
| Fred Luderus | 98 | 561 | 1921 | ||
| Harry Hooper * | 98 | 631 | 1915 | ||
| Buck Freeman | 98 | 652 | 1905 | ||
| 42. | Jim Bottomley | 97 | 620 | 1927 | |
| George Sisler | 97 | 612 | 1924 | ||
| George Sisler | 97 | 655 | 1922 | ||
| Harry Hooper * | 97 | 591 | 1922 | ||
| John Anderson | 97 | 649 | 1904 | ||
| Cy Seymour | 97 | 616 | 1904 | ||
| 48. | Dale Alexander | 96 | 626 | 1929 | |
| Del Howard | 96 | 639 | 1911 | ||
| Cy Seymour | 96 | 614 | 1905 | ||
| Dan McGann | 96 | 584 | 1902 | ||
| 52. | Cy Seymour | 95 | 606 | 1907 | |
| 53. | Snake Henry | 94 | 537 | 1926 | |
| Gavvy Cravath | 94 | 621 | 1911 | ||
| Harry Davis | 94 | 605 | 1903 | ||
| 56. | Fred Luderus | 93 | 611 | 1920 | |
| 57. | Lou Gehrig | 92 | 668 | 1927 | |
| Jim Bottomley | 92 | 646 | 1925 | ||
| Gavvy Cravath | 92 | 617 | 1914 | ||
| 60. | Bill Mellor | 91 | 589 | 1906 | |
| Mike Grady | 91 | 604 | 1903 | ||
| 62. | Paul Waner | 90 | 608 | 1929 | |
| George Sisler | 90 | 628 | 1926 | ||
| George Carr | 90 | 675 | 1923 | ||
| George Sisler | 90 | 653 | 1923 | ||
| Harry Hooper * | 90 | 636 | 1917 | ||
| Dick Hoblitzel | 90 | 627 | 1913 | ||
| Joe Kelley | 90 | 657 | 1904 | ||
| 69. | Lou Gehrig | 89 | 646 | 1928 | |
| John Anderson | 89 | 674 | 1905 | ||
| Dan McGann | 89 | 578 | 1901 | ||
| Candy Lachance | 89 | 542 | 1901 | ||
| 73. | Del Bissonette | 88 | 635 | 1928 | |
| George Carr | 88 | 627 | 1925 | ||
| George Carr | 88 | 670 | 1924 | ||
| Bill Mellor | 88 | 610 | 1907 | ||
| Joe Kelley | 88 | 609 | 1906 | ||
| 78. | Dick Hoblitzel | 87 | 610 | 1914 | |
| Fred Luderus | 87 | 623 | 1912 | ||
| 80. | Jimmie Foxx | 86 | 507 | 1928 | |
| Jimmy Hudgens | 86 | 506 | 1924 | ||
| George Grantham | 86 | 587 | 1923 | ||
| Ed Konetchy | 86 | 636 | 1917 | ||
| Dick Hoblitzel | 86 | 505 | 1912 | ||
| Harry Davis | 86 | 605 | 1907 | ||
| 86. | George Grantham | 85 | 595 | 1924 | |
| George Sisler | 85 | 634 | 1917 | ||
| Dick Hoblitzel | 85 | 521 | 1916 | ||
| Dan McGann | 85 | 605 | 1903 | ||
| 90. | Wally Pipp | 84 | 481 | 1926 | |
| Yam Yaryan | 84 | 548 | 1922 | ||
| Frank Isbell | 84 | 624 | 1904 | ||
| 93. | George Grantham | 83 | 620 | 1926 | |
| Stuffy McInnis | 83 | 613 | 1915 | ||
| John Anderson | 83 | 571 | 1902 | ||
| Harry Davis | 83 | 562 | 1901 | ||
| 97. | Bill Terry | 82 | 622 | 1928 | |
| Jimmy Hudgens | 82 | 599 | 1927 | ||
| Dick Hoblitzel | 82 | 589 | 1917 | ||
| Harry Hooper * | 82 | 653 | 1912 |
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