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| First Basemen Single-Season Slugging Pct Leaderboard | |
| * - Indicates Hall of Fame
+ - indicates hit-less at-bats added to meet 502PA requirement. |
| Rank | Player | Slugging Pct | PA | Year | Career Leaderboard |
| 1. | Lou Gehrig | .6194 | 637 | 1925 | |
| 2. | Lou Gehrig | .5893 | 584 | 1924 | |
| 3. | Lou Gehrig | .5739 | 639 | 1929 | |
| 4. | George Sisler | .5524 | 615 | 1921 | |
| 5. | George Carr | .5358 | 675 | 1923 | |
| 6. | Bill Kelly | .5353 | 638 | 1925 | |
| 7. | Buck Freeman | .5333 | 575 | 1901 | |
| 8. | Harry Hooper * | .5314 | 643 | 1913 | |
| 9. | George Sisler | .5310 | 655 | 1922 | |
| 10. | Lou Gehrig | .5310 | 628 | 1926 | |
| 11. | Harry Hooper * | .5277 | 591 | 1922 | |
| 12. | George Sisler | .5275 | 654 | 1925 | |
| 13. | Harry Davis | .5272 | 647 | 1904 | |
| 14. | John Anderson | .5255 | 602 | 1903 | |
| 15. | Harry Davis | .5232 | 680 | 1905 | |
| 16. | John Anderson | .5231 | 558 | 1901 | |
| 17. | Bill Kelly | .5216 | 648 | 1924 | |
| 18. | Harry Davis | .5210 | 605 | 1903 | |
| 19. | Snake Henry | .5186 | 537 | 1926 | |
| 20. | Dan McGann | .5174 | 605 | 1903 | |
| 21. | Joe Kelley | .5133 | 605 | 1903 | |
| 22. | Jim Bottomley | .5130 | 649 | 1923 | |
| 23. | Wally Pipp | .5121 | 540 | 1925 | |
| 24. | Joe Kelley | .5121 | 635 | 1905 | |
| 25. | Dale Alexander | .5098 | 626 | 1929 | |
| 26. | Bill Kelly | .5052 | 633 | 1923 | |
| 27. | Bill Kelly | .4991 | 625 | 1929 | |
| 28. | Paul Waner | .4991 | 608 | 1929 | |
| 29. | Buck Freeman | .4950 | 652 | 1905 | |
| 30. | Cy Seymour | .4943 | 576 | 1903 | |
| 31. | Joe Kelley | .4913 | 657 | 1904 | |
| 32. | Snake Henry | .4908 | 592 | 1925 | |
| 33. | Paul Waner | .4899 | 616 | 1927 | |
| 34. | Jim Bottomley | .4899 | 652 | 1924 | |
| 35. | Dick Hoblitzel | .4891+ | 488 | 1922 | |
| 36. | George Grantham | .4862 | 620 | 1926 | |
| 37. | Earl Webb | .4854 | 578 | 1925 | |
| 38. | George Sisler | .4840 | 612 | 1924 | |
| 39. | Jake Daubert | .4839+ | 485 | 1911 | |
| 40. | Jimmy Hudgens | .4836 | 576 | 1928 | |
| 41. | Bill Kelly | .4831 | 611 | 1926 | |
| 42. | George Sisler | .4827 | 633 | 1920 | |
| 43. | Bill Mellor | .4815 | 613 | 1904 | |
| 44. | Del Bissonette | .4808 | 583 | 1929 | |
| 45. | Cy Seymour | .4783 | 616 | 1904 | |
| 46. | Buck Freeman | .4780 | 592 | 1903 | |
| 47. | Bill Kelly | .4774 | 627 | 1928 | |
| 48. | Lou Gehrig | .4760 | 646 | 1928 | |
| 49. | Bill Kelly | .4759 | 613 | 1927 | |
| 50. | Hal Chase | .4753 | 607 | 1912 | |
| 51. | Bill Terry | .4713 | 629 | 1925 | |
| 52. | Buck Freeman | .4713 | 583 | 1902 | |
| 53. | George Carr | .4709 | 558 | 1928 | |
| 54. | Harry Hooper * | .4708 | 602 | 1911 | |
| 55. | Fred Luderus | .4708 | 627 | 1914 | |
| 56. | Dick Hoblitzel | .4702 | 505 | 1912 | |
| 57. | Wally Pipp | .4674+ | 481 | 1926 | |
| 58. | Harry Hooper * | .4644 | 525 | 1921 | |
| 59. | George Carr | .4629 | 627 | 1925 | |
| 60. | Lou Gehrig | .4626 | 668 | 1927 | |
| 61. | Frank Isbell | .4612 | 597 | 1903 | |
| 62. | Joe Judge | .4600 | 532 | 1921 | |
| 63. | Wally Pipp | .4599+ | 482 | 1924 | |
| 64. | Jimmy Hudgens | .4593+ | 472 | 1923 | |
| 65. | Hank Hulvey | .4580 | 682 | 1926 | |
| 66. | John Anderson | .4578 | 571 | 1902 | |
| 67. | Gavvy Cravath | .4564 | 550 | 1913 | |
| 68. | Fred Luderus | .4564 | 623 | 1912 | |
| 69. | Dick Hoblitzel | .4561 | 512 | 1923 | |
| 70. | Buck Freeman | .4555 | 636 | 1904 | |
| 71. | Jimmie Foxx | .4541 | 507 | 1928 | |
| 72. | George Carr | .4531 | 570 | 1927 | |
| 73. | Mike Grady | .4527 | 556 | 1902 | |
| 74. | Joe Kelley | .4526 | 573 | 1901 | |
| 75. | Bill Terry | .4523 | 622 | 1928 | |
| 76. | Mike Grady | .4522 | 602 | 1905 | |
| 77. | Don Hurst | .4520 | 572 | 1928 | |
| 78. | Earl Sheely | .4519 | 508 | 1921 | |
| 79. | Cy Seymour | .4513 | 614 | 1905 | |
| 80. | Hank Hulvey | .4500 | 681 | 1924 | |
| 81. | Jake Beckley | .4491 | 601 | 1903 | |
| 82. | Harry Hooper * | .4490 | 515 | 1919 | |
| 83. | Bill Terry | .4477+ | 487 | 1929 | |
| 84. | Kitty Bransfield | .4476 | 607 | 1904 | |
| 85. | Harry Davis | .4474 | 562 | 1901 | |
| 86. | George Sisler | .4467 | 659 | 1916 | |
| 87. | Stuffy McInnis | .4464 | 630 | 1912 | |
| 88. | Jim Bottomley | .4460 | 620 | 1927 | |
| 89. | George Grantham | .4460 | 587 | 1923 | |
| 90. | Jack Fournier | .4456 | 555 | 1912 | |
| 91. | Joe Judge | .4455 | 615 | 1920 | |
| 92. | George Sisler | .4450 | 599 | 1919 | |
| 93. | George Sisler | .4441 | 631 | 1928 | |
| 94. | Jimmy Hudgens | .4429 | 591 | 1926 | |
| 95. | Bill Terry | .4424 | 626 | 1926 | |
| 96. | Chick Gandil | .4422 | 604 | 1920 | |
| 97. | Ivy Griffin | .4422 | 585 | 1923 | |
| 98. | George Sisler | .4421 | 634 | 1917 | |
| 99. | Jimmy Hudgens | .4414 | 599 | 1927 | |
| 100. | Hal Chase | .4410 | 617 | 1913 |
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