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| First Basemen Single-Season Total Bases Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Total Bases | PA | Year | Career Leaderboard |
| 1. | Lou Gehrig | 345 | 637 | 1925 | |
| 2. | Harry Davis | 327 | 680 | 1905 | |
| 3. | George Carr | 322 | 675 | 1923 | |
| 4. | George Sisler | 317 | 655 | 1922 | |
| 5. | George Sisler | 316 | 654 | 1925 | |
| 6. | George Sisler | 311 | 615 | 1921 | |
| 7. | Harry Davis | 310 | 647 | 1904 | |
| 8. | Lou Gehrig | 307 | 584 | 1924 | |
| 9. | Lou Gehrig | 303 | 639 | 1929 | |
| Bill Kelly | 303 | 638 | 1925 | ||
| 11. | Bill Kelly | 302 | 648 | 1924 | |
| 12. | Jim Bottomley | 297 | 649 | 1923 | |
| Buck Freeman | 297 | 652 | 1905 | ||
| Joe Kelley | 297 | 635 | 1905 | ||
| 15. | Bill Kelly | 291 | 633 | 1923 | |
| 16. | Jim Bottomley | 290 | 652 | 1924 | |
| 17. | John Anderson | 289 | 602 | 1903 | |
| 18. | Harry Hooper * | 288 | 643 | 1913 | |
| 19. | Dale Alexander | 287 | 626 | 1929 | |
| 20. | Harry Davis | 285 | 605 | 1903 | |
| 21. | Joe Kelley | 284 | 657 | 1904 | |
| 22. | Lou Gehrig | 283 | 628 | 1926 | |
| 23. | George Sisler | 279 | 633 | 1920 | |
| 24. | Chick Gandil | 277 | 690 | 1912 | |
| 25. | Bill Kelly | 276 | 625 | 1929 | |
| Cy Seymour | 276 | 616 | 1904 | ||
| 27. | Bill Mellor | 274 | 613 | 1904 | |
| 28. | George Sisler | 272 | 612 | 1924 | |
| Buck Freeman | 272 | 575 | 1901 | ||
| John Anderson | 272 | 558 | 1901 | ||
| 31. | Bill Terry | 271 | 629 | 1925 | |
| Buck Freeman | 271 | 636 | 1904 | ||
| Joe Kelley | 271 | 605 | 1903 | ||
| 34. | Hal Chase | 269 | 607 | 1912 | |
| 35. | Paul Waner | 268 | 616 | 1927 | |
| Snake Henry | 268 | 592 | 1925 | ||
| George Sisler | 268 | 659 | 1916 | ||
| 38. | Harry Hooper * | 267 | 591 | 1922 | |
| 39. | Paul Waner | 266 | 608 | 1929 | |
| Fred Luderus | 266 | 627 | 1914 | ||
| 41. | George Grantham | 265 | 620 | 1926 | |
| 42. | Bill Kelly | 264 | 627 | 1928 | |
| 43. | George Sisler | 262 | 631 | 1928 | |
| Fred Luderus | 262 | 680 | 1911 | ||
| 45. | Cy Seymour | 261 | 576 | 1903 | |
| 46. | Lou Gehrig | 260 | 668 | 1927 | |
| 47. | Lou Gehrig | 258 | 646 | 1928 | |
| George Sisler | 258 | 628 | 1926 | ||
| Bill Kelly | 258 | 611 | 1926 | ||
| 50. | Bill Terry | 256 | 622 | 1928 | |
| Jim Bottomley | 256 | 620 | 1927 | ||
| Hank Hulvey | 256 | 682 | 1926 | ||
| George Carr | 256 | 627 | 1925 | ||
| George Sisler | 256 | 634 | 1917 | ||
| 55. | Chick Gandil | 255 | 659 | 1913 | |
| Cy Seymour | 255 | 614 | 1905 | ||
| John Anderson | 255 | 649 | 1904 | ||
| 58. | Wally Pipp | 254 | 540 | 1925 | |
| Hal Chase | 254 | 617 | 1913 | ||
| 60. | Jim Bottomley | 253 | 649 | 1922 | |
| Dan McGann | 253 | 605 | 1903 | ||
| 62. | Kitty Bransfield | 252 | 607 | 1904 | |
| 63. | Del Bissonette | 251 | 583 | 1929 | |
| Snake Henry | 251 | 537 | 1926 | ||
| George Sisler | 251 | 599 | 1919 | ||
| 66. | Earl Webb | 250 | 578 | 1925 | |
| Stuffy McInnis | 250 | 630 | 1912 | ||
| Buck Freeman | 250 | 592 | 1903 | ||
| 69. | Bill Kelly | 247 | 613 | 1927 | |
| George Sisler | 247 | 653 | 1923 | ||
| Jake Beckley | 247 | 601 | 1903 | ||
| 72. | Bill Terry | 246 | 626 | 1926 | |
| Fred Luderus | 246 | 623 | 1912 | ||
| Mike Grady | 246 | 602 | 1905 | ||
| Buck Freeman | 246 | 583 | 1902 | ||
| 76. | Del Bissonette | 245 | 635 | 1928 | |
| Jim Bottomley | 245 | 646 | 1925 | ||
| Frank Isbell | 245 | 624 | 1904 | ||
| 79. | John Anderson | 244 | 571 | 1902 | |
| 80. | Harry Hooper * | 242 | 602 | 1911 | |
| 81. | Chick Gandil | 241 | 604 | 1920 | |
| 82. | Kitty Bransfield | 238 | 662 | 1905 | |
| Frank Isbell | 238 | 597 | 1903 | ||
| 84. | Ivy Griffin | 237 | 585 | 1923 | |
| Joe Judge | 237 | 615 | 1920 | ||
| John Anderson | 237 | 608 | 1908 | ||
| Dan McGann | 237 | 697 | 1904 | ||
| 88. | Jimmy Hudgens | 236 | 576 | 1928 | |
| George Grantham | 236 | 617 | 1927 | ||
| George Sisler | 236 | 617 | 1927 | ||
| Mike Grady | 236 | 676 | 1904 | ||
| 92. | George Carr | 235 | 558 | 1928 | |
| Stuffy McInnis | 235 | 613 | 1915 | ||
| 94. | Joe Kelley | 234 | 573 | 1901 | |
| Harry Davis | 234 | 562 | 1901 | ||
| 96. | Fred Luderus | 233 | 624 | 1913 | |
| Dan McGann | 233 | 578 | 1901 | ||
| 98. | George Carr | 232 | 670 | 1924 | |
| Jake Beckley | 232 | 608 | 1905 | ||
| 100. | George Grantham | 231 | 595 | 1924 |
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