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| Second Basemen Career Singles Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Singles | PA | Years | Single Season Leaderboard |
| 1. | Amby McConnell | 1938 | 8500 | 1908-1923 | |
| 2. | Del Pratt | 1798 | 7838 | 1912-1924 | |
| 3. | Jimmy Williams * | 1749 | 9454 | 1901-1915 | |
| 4. | Frank O'Rourke | 1701 | 7820 | 1914-1928 | |
| 5. | Rogers Hornsby | 1556 | 8145 | 1915-1929 | |
| 6. | Lee Magee | 1553 | 7727 | 1911-1925 | |
| 7. | Bill Sweeney | 1517 | 8310 | 1907-1921 | |
| 8. | Nap Lajoie * | 1513 | 7574 | 1901-1913 | |
| 9. | Heinie Groh | 1440 | 6878 | 1912-1929 | |
| 10. | Larry Hoffman | 1436 | 7031 | 1901-1915 | |
| 11. | Gene Demontreville | 1393 | 6048 | 1901-1912 | |
| 12. | Larry Doyle | 1359 | 6994 | 1909-1922 | |
| 13. | Erve Beck | 1269 | 6635 | 1901-1913 | |
| 14. | Johnny Rawlings | 1169 | 5672 | 1915-1929 | |
| 15. | Ossie Vitt | 1117 | 5643 | 1915-1926 | |
| 16. | Frank Laporte | 1113 | 5690 | 1907-1918 | |
| 17. | Danny Murphy | 1064 | 5528 | 1901-1912 | |
| 18. | Joe Gedeon | 1034 | 4635 | 1919-1929 | |
| 19. | Bucky Harris | 994 | 5068 | 1919-1929 | |
| 20. | Charlie Hollocher | 989 | 5276 | 1918-1929 | |
| 21. | Jay Kirke | 974 | 4446 | 1913-1924 | |
| 22. | George Scales | 927 | 5077 | 1920-1929 | |
| 23. | Tom Jones | 926 | 4233 | 1907-1914 | |
| 24. | Sparky Adams | 907 | 3778 | 1922-1929 | |
| 25. | Marty McManus | 890 | 4679 | 1920-1929 | |
| 26. | Riggs Stephenson | 885 | 4545 | 1921-1929 | |
| 27. | Lefty Davis | 879 | 4861 | 1901-1911 | |
| 28. | Gene Paulette | 867 | 4173 | 1914-1926 | |
| 29. | Whitey Witt | 839 | 4363 | 1919-1927 | |
| 30. | Roy Grimes | 835 | 3598 | 1922-1929 | |
| 31. | Bill O'Neill | 816 | 3655 | 1905-1913 | |
| 32. | Walter Barbare | 808 | 3590 | 1915-1927 | |
| 33. | Bingo Demoss | 759 | 4286 | 1918-1926 | |
| 34. | Miller Huggins | 737 | 4144 | 1904-1915 | |
| 35. | Morrie Rath | 733 | 3491 | 1911-1922 | |
| 36. | Jesse Baker | 717 | 3663 | 1919-1929 | |
| 37. | Clyde Engle | 696 | 3913 | 1909-1920 | |
| Charlie Malay | 696 | 3471 | 1906-1917 | ||
| 39. | John Godwin | 689 | 3875 | 1906-1913 | |
| 40. | George Kelly | 688 | 3133 | 1916-1926 | |
| 41. | Frankie Frisch | 676 | 4216 | 1919-1928 | |
| 42. | Dave Brain | 671 | 4237 | 1901-1910 | |
| 43. | John Monroe | 662 | 3253 | 1921-1929 | |
| 44. | Sam Mertes | 658 | 3954 | 1901-1908 | |
| 45. | Marty Kavanagh | 652 | 3316 | 1916-1926 | |
| 46. | John Farrell | 647 | 3627 | 1901-1911 | |
| 47. | Bert Conn | 579 | 3564 | 1901-1914 | |
| 48. | Charlie Gehringer | 577 | 3255 | 1924-1929 | |
| 49. | Tillie Shafer | 576 | 3198 | 1914-1925 | |
| 50. | Max Bishop | 565 | 3336 | 1924-1929 | |
| 51. | John Jenkins | 561 | 2633 | 1922-1929 | |
| 52. | Jackie Tavener | 558 | 2701 | 1924-1929 | |
| John Leary | 558 | 2590 | 1915-1925 | ||
| 54. | Jack Mills | 541 | 2141 | 1914-1924 | |
| 55. | Dusty Miller | 536 | 2627 | 1902-1915 | |
| 56. | Lloyd Christenbury | 534 | 2636 | 1919-1926 | |
| 57. | Jimmie Dykes | 498 | 2970 | 1919-1929 | |
| 58. | Pete Childs | 461 | 2680 | 1901-1908 | |
| 59. | John Hummel | 443 | 2366 | 1910-1919 | |
| 60. | Frank Warfield | 415 | 2496 | 1926-1929 | |
| 61. | Sam Bohne | 414 | 2233 | 1922-1929 | |
| 62. | Buddy Myer | 412 | 2080 | 1925-1929 | |
| 63. | Cotton Tierney | 411 | 1875 | 1920-1929 | |
| 64. | Lee Tannehill | 408 | 2279 | 1905-1914 | |
| 65. | Ivy Olson | 404 | 2079 | 1911-1919 | |
| 66. | Tony Lazzeri | 397 | 2267 | 1926-1929 | |
| 67. | Art Griggs | 394 | 2332 | 1909-1919 | |
| 68. | Jack Morrissey | 370 | 2058 | 1902-1910 | |
| 69. | Cupid Childs | 328 | 1912 | 1901-1904 | |
| 70. | Paddy Baumann | 304 | 1509 | 1912-1920 | |
| 71. | Luis Castro | 294 | 1895 | 1902-1907 | |
| 72. | Ethan Allen | 274 | 1322 | 1927-1929 | |
| 73. | Wally Gerber | 254 | 1272 | 1917-1921 | |
| Bobby Lowe | 254 | 1400 | 1901-1903 | ||
| 75. | Benny Bowcock | 251 | 1627 | 1903-1912 | |
| 76. | Marty Berghammer | 247 | 1632 | 1916-1920 | |
| 77. | Kid Gleason | 239 | 1229 | 1901-1904 | |
| 78. | Ralph Young | 232 | 1190 | 1913-1922 | |
| 79. | Johnny Hodapp | 212 | 1115 | 1925-1929 | |
| 80. | Dutch Jordan | 196 | 1206 | 1903-1910 | |
| 81. | Mike Donovan | 193 | 1012 | 1908-1915 | |
| 82. | Jack Burns | 190 | 1120 | 1904-1913 | |
| 83. | Jim Viox | 181 | 1026 | 1916-1922 | |
| 84. | Joe Dugan | 172 | 837 | 1925-1928 | |
| Mike McCormick | 172 | 1056 | 1909-1911 | ||
| 86. | Hal Leathers | 157 | 838 | 1921-1929 | |
| 87. | Guy Tutwiler | 153 | 775 | 1916-1924 | |
| 88. | Heinie Scheer | 151 | 789 | 1925-1929 | |
| 89. | Carl Lind | 142 | 697 | 1928-1929 | |
| 90. | Bruno Betzel | 141 | 652 | 1920-1923 | |
| 91. | Tom Daly | 132 | 611 | 1901-1902 | |
| 92. | Shag Shaughnessy | 131 | 567 | 1911-1916 | |
| 93. | Peaches Graham | 130 | 793 | 1910-1914 | |
| 94. | Ossie Bluege | 127 | 703 | 1923-1926 | |
| Roy Hartzell | 127 | 713 | 1908-1918 | ||
| 96. | Joe Dolan | 124 | 1029 | 1901-1909 | |
| 97. | John Knight | 123 | 788 | 1911-1919 | |
| 98. | Andy Cohen | 121 | 677 | 1927-1929 | |
| 99. | Jack Rothrock | 117 | 579 | 1925-1929 | |
| 100. | Gus Dundon | 97 | 575 | 1904-1908 |
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