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| Second Basemen Career Doubles Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Doubles | PA | Years | Single Season Leaderboard |
| 1. | Nap Lajoie * | 498 | 7574 | 1901-1913 | |
| 2. | Jimmy Williams * | 427 | 9454 | 1901-1915 | |
| 3. | Rogers Hornsby | 370 | 8145 | 1915-1929 | |
| 4. | Erve Beck | 321 | 6635 | 1901-1913 | |
| 5. | Lee Magee | 307 | 7727 | 1911-1925 | |
| 6. | Frank O'Rourke | 303 | 7820 | 1914-1928 | |
| 7. | Del Pratt | 297 | 7838 | 1912-1924 | |
| 8. | Danny Murphy | 288 | 5528 | 1901-1912 | |
| 9. | Bert Conn | 275 | 3564 | 1901-1914 | |
| 10. | Riggs Stephenson | 266 | 4545 | 1921-1929 | |
| 11. | Larry Doyle | 260 | 6994 | 1909-1922 | |
| 12. | Larry Hoffman | 248 | 7031 | 1901-1915 | |
| 13. | Marty McManus | 245 | 4679 | 1920-1929 | |
| Dave Brain | 245 | 4237 | 1901-1910 | ||
| 15. | Bill Sweeney | 239 | 8310 | 1907-1921 | |
| 16. | Charlie Hollocher | 224 | 5276 | 1918-1929 | |
| 17. | Bucky Harris | 216 | 5068 | 1919-1929 | |
| 18. | Heinie Groh | 207 | 6878 | 1912-1929 | |
| 19. | Amby McConnell | 204 | 8500 | 1908-1923 | |
| 20. | John Farrell | 193 | 3627 | 1901-1911 | |
| 21. | Gene Demontreville | 192 | 6048 | 1901-1912 | |
| 22. | Frankie Frisch | 189 | 4216 | 1919-1928 | |
| Sam Mertes | 189 | 3954 | 1901-1908 | ||
| 24. | Frank Laporte | 188 | 5690 | 1907-1918 | |
| 25. | Charlie Gehringer | 183 | 3255 | 1924-1929 | |
| 26. | Ossie Vitt | 180 | 5643 | 1915-1926 | |
| 27. | Whitey Witt | 177 | 4363 | 1919-1927 | |
| 28. | George Scales | 162 | 5077 | 1920-1929 | |
| 29. | Jay Kirke | 159 | 4446 | 1913-1924 | |
| 30. | Joe Gedeon | 158 | 4635 | 1919-1929 | |
| 31. | Gene Paulette | 157 | 4173 | 1914-1926 | |
| 32. | Max Bishop | 156 | 3336 | 1924-1929 | |
| 33. | Roy Grimes | 150 | 3598 | 1922-1929 | |
| George Kelly | 150 | 3133 | 1916-1926 | ||
| 35. | Lefty Davis | 148 | 4861 | 1901-1911 | |
| 36. | Marty Kavanagh | 144 | 3316 | 1916-1926 | |
| 37. | Jimmie Dykes | 142 | 2970 | 1919-1929 | |
| 38. | Jackie Tavener | 141 | 2701 | 1924-1929 | |
| 39. | Tony Lazzeri | 139 | 2267 | 1926-1929 | |
| 40. | Jesse Baker | 133 | 3663 | 1919-1929 | |
| 41. | Bingo Demoss | 132 | 4286 | 1918-1926 | |
| 42. | Johnny Rawlings | 129 | 5672 | 1915-1929 | |
| 43. | Tom Jones | 123 | 4233 | 1907-1914 | |
| 44. | Sparky Adams | 121 | 3778 | 1922-1929 | |
| 45. | Luis Castro | 119 | 1895 | 1902-1907 | |
| 46. | Clyde Engle | 117 | 3913 | 1909-1920 | |
| 47. | Miller Huggins | 107 | 4144 | 1904-1915 | |
| 48. | John Monroe | 104 | 3253 | 1921-1929 | |
| Art Griggs | 104 | 2332 | 1909-1919 | ||
| 50. | Cotton Tierney | 102 | 1875 | 1920-1929 | |
| 51. | Walter Barbare | 98 | 3590 | 1915-1927 | |
| 52. | Benny Bowcock | 96 | 1627 | 1903-1912 | |
| 53. | Lloyd Christenbury | 95 | 2636 | 1919-1926 | |
| 54. | John Leary | 93 | 2590 | 1915-1925 | |
| 55. | Tillie Shafer | 92 | 3198 | 1914-1925 | |
| 56. | Sam Bohne | 89 | 2233 | 1922-1929 | |
| 57. | Buddy Myer | 87 | 2080 | 1925-1929 | |
| Bill O'Neill | 87 | 3655 | 1905-1913 | ||
| 59. | John Jenkins | 84 | 2633 | 1922-1929 | |
| 60. | Ethan Allen | 80 | 1322 | 1927-1929 | |
| 61. | Lee Tannehill | 77 | 2279 | 1905-1914 | |
| 62. | John Hummel | 72 | 2366 | 1910-1919 | |
| 63. | Frank Warfield | 71 | 2496 | 1926-1929 | |
| 64. | Pete Childs | 68 | 2680 | 1901-1908 | |
| 65. | Ivy Olson | 66 | 2079 | 1911-1919 | |
| 66. | Cupid Childs | 64 | 1912 | 1901-1904 | |
| 67. | John Godwin | 61 | 3875 | 1906-1913 | |
| 68. | Johnny Hodapp | 58 | 1115 | 1925-1929 | |
| Dusty Miller | 58 | 2627 | 1902-1915 | ||
| 70. | Jack Morrissey | 51 | 2058 | 1902-1910 | |
| 71. | Morrie Rath | 50 | 3491 | 1911-1922 | |
| 72. | Charlie Malay | 49 | 3471 | 1906-1917 | |
| Bobby Lowe | 49 | 1400 | 1901-1903 | ||
| 74. | Jack Burns | 45 | 1120 | 1904-1913 | |
| 75. | Joe Dugan | 44 | 837 | 1925-1928 | |
| 76. | Chink Heileman | 42 | 839 | 1901-1905 | |
| Kid Gleason | 42 | 1229 | 1901-1904 | ||
| 78. | Carl Lind | 41 | 697 | 1928-1929 | |
| Jack Mills | 41 | 2141 | 1914-1924 | ||
| Jim Viox | 41 | 1026 | 1916-1922 | ||
| 81. | Joe Dolan | 40 | 1029 | 1901-1909 | |
| 82. | Marty Berghammer | 37 | 1632 | 1916-1920 | |
| 83. | Mike Donovan | 36 | 1012 | 1908-1915 | |
| 84. | Andy Cohen | 34 | 677 | 1927-1929 | |
| Dutch Jordan | 34 | 1206 | 1903-1910 | ||
| 86. | Heinie Scheer | 33 | 789 | 1925-1929 | |
| Paddy Baumann | 33 | 1509 | 1912-1920 | ||
| 88. | Wally Gerber | 32 | 1272 | 1917-1921 | |
| 89. | Ralph Young | 31 | 1190 | 1913-1922 | |
| 90. | Hal Leathers | 30 | 838 | 1921-1929 | |
| 91. | Charlie Buelow | 25 | 420 | 1901-1905 | |
| 92. | John Knight | 24 | 788 | 1911-1919 | |
| 93. | Jack Rothrock | 22 | 579 | 1925-1929 | |
| 94. | Herb Thomas | 21 | 515 | 1927-1929 | |
| Ossie Bluege | 21 | 703 | 1923-1926 | ||
| 96. | Guy Tutwiler | 20 | 775 | 1916-1924 | |
| 97. | Peaches Graham | 18 | 793 | 1910-1914 | |
| 98. | Mike McCormick | 17 | 1056 | 1909-1911 | |
| 99. | Ray Morehart | 15 | 190 | 1924-1924 | |
| Dick Egan | 15 | 454 | 1915-1916 |
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