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| Second Basemen Career Hits Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Hits | PA | Years | Single Season Leaderboard |
| 1. | Jimmy Williams * | 2413 | 9454 | 1901-1915 | |
| 2. | Amby McConnell | 2267 | 8500 | 1908-1923 | |
| 3. | Del Pratt | 2250 | 7838 | 1912-1924 | |
| 4. | Rogers Hornsby | 2231 | 8145 | 1915-1929 | |
| 5. | Nap Lajoie * | 2229 | 7574 | 1901-1913 | |
| 6. | Frank O'Rourke | 2128 | 7820 | 1914-1928 | |
| 7. | Lee Magee | 2039 | 7727 | 1911-1925 | |
| 8. | Bill Sweeney | 1883 | 8310 | 1907-1921 | |
| 9. | Larry Doyle | 1795 | 6994 | 1909-1922 | |
| 10. | Larry Hoffman | 1781 | 7031 | 1901-1915 | |
| 11. | Heinie Groh | 1739 | 6878 | 1912-1929 | |
| 12. | Erve Beck | 1721 | 6635 | 1901-1913 | |
| 13. | Gene Demontreville | 1672 | 6048 | 1901-1912 | |
| 14. | Danny Murphy | 1481 | 5528 | 1901-1912 | |
| 15. | Frank Laporte | 1409 | 5690 | 1907-1918 | |
| 16. | Ossie Vitt | 1397 | 5643 | 1915-1926 | |
| 17. | Johnny Rawlings | 1379 | 5672 | 1915-1929 | |
| 18. | Charlie Hollocher | 1353 | 5276 | 1918-1929 | |
| 19. | Bucky Harris | 1317 | 5068 | 1919-1929 | |
| 20. | Joe Gedeon | 1252 | 4635 | 1919-1929 | |
| 21. | Jay Kirke | 1245 | 4446 | 1913-1924 | |
| 22. | Riggs Stephenson | 1232 | 4545 | 1921-1929 | |
| 23. | Marty McManus | 1228 | 4679 | 1920-1929 | |
| 24. | George Scales | 1160 | 5077 | 1920-1929 | |
| 25. | Tom Jones | 1104 | 4233 | 1907-1914 | |
| 26. | Sparky Adams | 1096 | 3778 | 1922-1929 | |
| 27. | Whitey Witt | 1091 | 4363 | 1919-1927 | |
| 28. | Gene Paulette | 1083 | 4173 | 1914-1926 | |
| 29. | Lefty Davis | 1081 | 4861 | 1901-1911 | |
| 30. | Roy Grimes | 1060 | 3598 | 1922-1929 | |
| 31. | Frankie Frisch | 1015 | 4216 | 1919-1928 | |
| 32. | Dave Brain | 1007 | 4237 | 1901-1910 | |
| 33. | Bingo Demoss | 997 | 4286 | 1918-1926 | |
| 34. | Jesse Baker | 964 | 3663 | 1919-1929 | |
| 35. | Sam Mertes | 960 | 3954 | 1901-1908 | |
| 36. | Walter Barbare | 954 | 3590 | 1915-1927 | |
| 37. | Bill O'Neill | 937 | 3655 | 1905-1913 | |
| 38. | John Farrell | 910 | 3627 | 1901-1911 | |
| 39. | Bert Conn | 888 | 3564 | 1901-1914 | |
| 40. | George Kelly | 887 | 3133 | 1916-1926 | |
| 41. | Clyde Engle | 878 | 3913 | 1909-1920 | |
| 42. | Miller Huggins | 874 | 4144 | 1904-1915 | |
| 43. | John Monroe | 842 | 3253 | 1921-1929 | |
| Morrie Rath | 842 | 3491 | 1911-1922 | ||
| 45. | Marty Kavanagh | 829 | 3316 | 1916-1926 | |
| 46. | Charlie Gehringer | 827 | 3255 | 1924-1929 | |
| 47. | John Godwin | 787 | 3875 | 1906-1913 | |
| 48. | Charlie Malay | 776 | 3471 | 1906-1917 | |
| 49. | Max Bishop | 767 | 3336 | 1924-1929 | |
| 50. | Jackie Tavener | 761 | 2701 | 1924-1929 | |
| 51. | Tillie Shafer | 748 | 3198 | 1914-1925 | |
| 52. | Jimmie Dykes | 723 | 2970 | 1919-1929 | |
| 53. | Lloyd Christenbury | 700 | 2636 | 1919-1926 | |
| 54. | John Leary | 692 | 2590 | 1915-1925 | |
| 55. | John Jenkins | 679 | 2633 | 1922-1929 | |
| 56. | Dusty Miller | 626 | 2627 | 1902-1915 | |
| 57. | Tony Lazzeri | 603 | 2267 | 1926-1929 | |
| 58. | Jack Mills | 598 | 2141 | 1914-1924 | |
| 59. | John Hummel | 561 | 2366 | 1910-1919 | |
| 60. | Sam Bohne | 558 | 2233 | 1922-1929 | |
| 61. | Frank Warfield | 550 | 2496 | 1926-1929 | |
| 62. | Cotton Tierney | 547 | 1875 | 1920-1929 | |
| 63. | Buddy Myer | 543 | 2080 | 1925-1929 | |
| Pete Childs | 543 | 2680 | 1901-1908 | ||
| 65. | Art Griggs | 537 | 2332 | 1909-1919 | |
| 66. | Lee Tannehill | 519 | 2279 | 1905-1914 | |
| 67. | Ivy Olson | 501 | 2079 | 1911-1919 | |
| 68. | Jack Morrissey | 439 | 2058 | 1902-1910 | |
| 69. | Luis Castro | 437 | 1895 | 1902-1907 | |
| 70. | Cupid Childs | 432 | 1912 | 1901-1904 | |
| 71. | Benny Bowcock | 394 | 1627 | 1903-1912 | |
| 72. | Ethan Allen | 381 | 1322 | 1927-1929 | |
| 73. | Paddy Baumann | 351 | 1509 | 1912-1920 | |
| 74. | Bobby Lowe | 324 | 1400 | 1901-1903 | |
| 75. | Marty Berghammer | 303 | 1632 | 1916-1920 | |
| 76. | Wally Gerber | 300 | 1272 | 1917-1921 | |
| 77. | Kid Gleason | 298 | 1229 | 1901-1904 | |
| 78. | Johnny Hodapp | 291 | 1115 | 1925-1929 | |
| 79. | Ralph Young | 277 | 1190 | 1913-1922 | |
| 80. | Dutch Jordan | 244 | 1206 | 1903-1910 | |
| 81. | Jack Burns | 243 | 1120 | 1904-1913 | |
| 82. | Mike Donovan | 239 | 1012 | 1908-1915 | |
| 83. | Jim Viox | 231 | 1026 | 1916-1922 | |
| 84. | Joe Dugan | 228 | 837 | 1925-1928 | |
| 85. | Heinie Scheer | 204 | 789 | 1925-1929 | |
| Mike McCormick | 204 | 1056 | 1909-1911 | ||
| 87. | Hal Leathers | 201 | 838 | 1921-1929 | |
| 88. | Carl Lind | 191 | 697 | 1928-1929 | |
| 89. | Guy Tutwiler | 179 | 775 | 1916-1924 | |
| 90. | Joe Dolan | 174 | 1029 | 1901-1909 | |
| 91. | Andy Cohen | 170 | 677 | 1927-1929 | |
| 92. | Bruno Betzel | 164 | 652 | 1920-1923 | |
| 93. | Tom Daly | 159 | 611 | 1901-1902 | |
| 94. | John Knight | 158 | 788 | 1911-1919 | |
| 95. | Peaches Graham | 157 | 793 | 1910-1914 | |
| 96. | Ossie Bluege | 156 | 703 | 1923-1926 | |
| 97. | Jack Rothrock | 148 | 579 | 1925-1929 | |
| 98. | Chink Heileman | 147 | 839 | 1901-1905 | |
| 99. | Roy Hartzell | 146 | 713 | 1908-1918 | |
| 100. | Shag Shaughnessy | 141 | 567 | 1911-1916 |
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