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| Second Basemen Career On-Base Pct Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | On-Base Pct | PA | Years | Single Season Leaderboard |
| 1. | Max Bishop | .3898 | 3336 | 1924-1929 | |
| 2. | Rogers Hornsby | .3871 | 8145 | 1915-1929 | |
| 3. | Nap Lajoie * | .3752 | 7574 | 1901-1913 | |
| 4. | Heinie Groh | .3724 | 6878 | 1912-1929 | |
| 5. | Roy Grimes | .3708 | 3598 | 1922-1929 | |
| 6. | Riggs Stephenson | .3698 | 4545 | 1921-1929 | |
| 7. | Jimmy Williams * | .3691 | 9454 | 1901-1915 | |
| 8. | Amby McConnell | .3689 | 8500 | 1908-1923 | |
| 9. | Morrie Rath | .3654 | 3491 | 1911-1922 | |
| 10. | Lefty Davis | .3643 | 4861 | 1901-1911 | |
| 11. | Miller Huggins | .3616 | 4144 | 1904-1915 | |
| 12. | Sparky Adams | .3583 | 3778 | 1922-1929 | |
| 13. | Larry Doyle | .3580 | 6994 | 1909-1922 | |
| 14. | George Scales | .3573 | 5077 | 1920-1929 | |
| 15. | Del Pratt | .3567 | 7838 | 1912-1924 | |
| 16. | George Kelly | .3565 | 3133 | 1916-1926 | |
| 17. | Joe Gedeon | .3563 | 4635 | 1919-1929 | |
| 18. | Ossie Vitt | .3527 | 5643 | 1915-1926 | |
| 19. | Whitey Witt | .3524 | 4363 | 1919-1927 | |
| 20. | Bucky Harris | .3501 | 5068 | 1919-1929 | |
| 21. | John Monroe | .3491 | 3253 | 1921-1929 | |
| 22. | Sam Mertes | .3470 | 3954 | 1901-1908 | |
| 23. | Lee Magee | .3431 | 7727 | 1911-1925 | |
| 24. | Charlie Hollocher | .3428 | 5276 | 1918-1929 | |
| 25. | Jesse Baker | .3403 | 3663 | 1919-1929 | |
| 26. | Frank O'Rourke | .3397 | 7820 | 1914-1928 | |
| 27. | Bill O'Neill | .3396 | 3655 | 1905-1913 | |
| 28. | Charlie Gehringer | .3379 | 3255 | 1924-1929 | |
| 29. | Frank Laporte | .3349 | 5690 | 1907-1918 | |
| 30. | Clyde Engle | .3345 | 3913 | 1909-1920 | |
| 31. | Marty Kavanagh | .3338 | 3316 | 1916-1926 | |
| 32. | Marty McManus | .3338 | 4679 | 1920-1929 | |
| 33. | Tom Jones | .3338 | 4233 | 1907-1914 | |
| 34. | Danny Murphy | .3333 | 5528 | 1901-1912 | |
| 35. | Larry Hoffman | .3305 | 7031 | 1901-1915 | |
| 36. | John Farrell | .3305 | 3627 | 1901-1911 | |
| 37. | Bill Sweeney | .3301 | 8310 | 1907-1921 | |
| 38. | Gene Paulette | .3285 | 4173 | 1914-1926 | |
| 39. | Johnny Rawlings | .3206 | 5672 | 1915-1929 | |
| 40. | Gene Demontreville | .3144 | 6048 | 1901-1912 | |
| 41. | Jay Kirke | .3142 | 4446 | 1913-1924 | |
| 42. | Walter Barbare | .3136 | 3590 | 1915-1927 | |
| 43. | Bingo Demoss | .3119 | 4286 | 1918-1926 | |
| 44. | Frankie Frisch | .3092 | 4216 | 1919-1928 | |
| 45. | Tillie Shafer | .3042 | 3198 | 1914-1925 | |
| 46. | Erve Beck | .3034 | 6635 | 1901-1913 | |
| 47. | Charlie Malay | .2938 | 3471 | 1906-1917 | |
| 48. | Dave Brain | .2919 | 4237 | 1901-1910 | |
| 49. | John Godwin | .2891 | 3875 | 1906-1913 | |
| 50. | Bert Conn | .2858 | 3564 | 1901-1914 |
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