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| Second Basemen Career Total Bases Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Total Bases | PA | Years | Single Season Leaderboard |
| 1. | Jimmy Williams * | 3387 | 9454 | 1901-1915 | |
| 2. | Rogers Hornsby | 3362 | 8145 | 1915-1929 | |
| 3. | Nap Lajoie * | 3239 | 7574 | 1901-1913 | |
| 4. | Del Pratt | 2894 | 7838 | 1912-1924 | |
| 5. | Amby McConnell | 2765 | 8500 | 1908-1923 | |
| 6. | Lee Magee | 2755 | 7727 | 1911-1925 | |
| 7. | Frank O'Rourke | 2703 | 7820 | 1914-1928 | |
| 8. | Larry Doyle | 2465 | 6994 | 1909-1922 | |
| 9. | Bill Sweeney | 2413 | 8310 | 1907-1921 | |
| 10. | Erve Beck | 2348 | 6635 | 1901-1913 | |
| 11. | Larry Hoffman | 2263 | 7031 | 1901-1915 | |
| 12. | Heinie Groh | 2148 | 6878 | 1912-1929 | |
| 13. | Gene Demontreville | 2067 | 6048 | 1901-1912 | |
| 14. | Danny Murphy | 2058 | 5528 | 1901-1912 | |
| 15. | Charlie Hollocher | 1896 | 5276 | 1918-1929 | |
| 16. | Frank Laporte | 1835 | 5690 | 1907-1918 | |
| 17. | Ossie Vitt | 1810 | 5643 | 1915-1926 | |
| 18. | Bucky Harris | 1763 | 5068 | 1919-1929 | |
| 19. | Johnny Rawlings | 1710 | 5672 | 1915-1929 | |
| 20. | Marty McManus | 1692 | 4679 | 1920-1929 | |
| 21. | Riggs Stephenson | 1690 | 4545 | 1921-1929 | |
| 22. | Jay Kirke | 1675 | 4446 | 1913-1924 | |
| 23. | Frankie Frisch | 1554 | 4216 | 1919-1928 | |
| 24. | Joe Gedeon | 1551 | 4635 | 1919-1929 | |
| 25. | George Scales | 1495 | 5077 | 1920-1929 | |
| 26. | Dave Brain | 1466 | 4237 | 1901-1910 | |
| 27. | Whitey Witt | 1438 | 4363 | 1919-1927 | |
| 28. | Sam Mertes | 1412 | 3954 | 1901-1908 | |
| 29. | Roy Grimes | 1376 | 3598 | 1922-1929 | |
| 30. | Gene Paulette | 1373 | 4173 | 1914-1926 | |
| 31. | Sparky Adams | 1371 | 3778 | 1922-1929 | |
| 32. | Bingo Demoss | 1358 | 4286 | 1918-1926 | |
| 33. | Lefty Davis | 1353 | 4861 | 1901-1911 | |
| 34. | Tom Jones | 1348 | 4233 | 1907-1914 | |
| 35. | Jesse Baker | 1346 | 3663 | 1919-1929 | |
| 36. | John Farrell | 1264 | 3627 | 1901-1911 | |
| 37. | Bert Conn | 1248 | 3564 | 1901-1914 | |
| 38. | Walter Barbare | 1166 | 3590 | 1915-1927 | |
| 39. | Charlie Gehringer | 1164 | 3255 | 1924-1929 | |
| 40. | George Kelly | 1156 | 3133 | 1916-1926 | |
| 41. | Clyde Engle | 1136 | 3913 | 1909-1920 | |
| 42. | John Monroe | 1124 | 3253 | 1921-1929 | |
| 43. | Bill O'Neill | 1107 | 3655 | 1905-1913 | |
| 44. | Jimmie Dykes | 1061 | 2970 | 1919-1929 | |
| 45. | Marty Kavanagh | 1044 | 3316 | 1916-1926 | |
| 46. | Miller Huggins | 1042 | 4144 | 1904-1915 | |
| 47. | Max Bishop | 1039 | 3336 | 1924-1929 | |
| Jackie Tavener | 1039 | 2701 | 1924-1929 | ||
| 49. | Tillie Shafer | 1030 | 3198 | 1914-1925 | |
| 50. | Morrie Rath | 1028 | 3491 | 1911-1922 | |
| 51. | Lloyd Christenbury | 960 | 2636 | 1919-1926 | |
| 52. | John Godwin | 939 | 3875 | 1906-1913 | |
| 53. | Tony Lazzeri | 906 | 2267 | 1926-1929 | |
| 54. | Charlie Malay | 897 | 3471 | 1906-1917 | |
| 55. | John Leary | 878 | 2590 | 1915-1925 | |
| 56. | John Jenkins | 845 | 2633 | 1922-1929 | |
| 57. | Sam Bohne | 772 | 2233 | 1922-1929 | |
| 58. | Dusty Miller | 763 | 2627 | 1902-1915 | |
| 59. | Frank Warfield | 756 | 2496 | 1926-1929 | |
| 60. | John Hummel | 739 | 2366 | 1910-1919 | |
| 61. | Buddy Myer | 735 | 2080 | 1925-1929 | |
| 62. | Cotton Tierney | 731 | 1875 | 1920-1929 | |
| 63. | Art Griggs | 725 | 2332 | 1909-1919 | |
| 64. | Jack Mills | 679 | 2141 | 1914-1924 | |
| 65. | Lee Tannehill | 674 | 2279 | 1905-1914 | |
| 66. | Pete Childs | 645 | 2680 | 1901-1908 | |
| 67. | Ivy Olson | 635 | 2079 | 1911-1919 | |
| 68. | Luis Castro | 615 | 1895 | 1902-1907 | |
| 69. | Benny Bowcock | 603 | 1627 | 1903-1912 | |
| 70. | Cupid Childs | 595 | 1912 | 1901-1904 | |
| 71. | Jack Morrissey | 533 | 2058 | 1902-1910 | |
| 72. | Ethan Allen | 520 | 1322 | 1927-1929 | |
| 73. | Bobby Lowe | 423 | 1400 | 1901-1903 | |
| 74. | Paddy Baumann | 413 | 1509 | 1912-1920 | |
| 75. | Johnny Hodapp | 398 | 1115 | 1925-1929 | |
| 76. | Marty Berghammer | 385 | 1632 | 1916-1920 | |
| 77. | Kid Gleason | 382 | 1229 | 1901-1904 | |
| 78. | Wally Gerber | 368 | 1272 | 1917-1921 | |
| 79. | Ralph Young | 338 | 1190 | 1913-1922 | |
| 80. | Jack Burns | 308 | 1120 | 1904-1913 | |
| Dutch Jordan | 308 | 1206 | 1903-1910 | ||
| 82. | Mike Donovan | 303 | 1012 | 1908-1915 | |
| 83. | Joe Dugan | 300 | 837 | 1925-1928 | |
| 84. | Jim Viox | 293 | 1026 | 1916-1922 | |
| 85. | Heinie Scheer | 287 | 789 | 1925-1929 | |
| 86. | Hal Leathers | 269 | 838 | 1921-1929 | |
| 87. | Mike McCormick | 255 | 1056 | 1909-1911 | |
| 88. | Carl Lind | 249 | 697 | 1928-1929 | |
| 89. | Andy Cohen | 243 | 677 | 1927-1929 | |
| 90. | Joe Dolan | 239 | 1029 | 1901-1909 | |
| 91. | Chink Heileman | 238 | 839 | 1901-1905 | |
| 92. | Guy Tutwiler | 211 | 775 | 1916-1924 | |
| 93. | John Knight | 205 | 788 | 1911-1919 | |
| 94. | Tom Daly | 204 | 611 | 1901-1902 | |
| 95. | Bruno Betzel | 199 | 652 | 1920-1923 | |
| 96. | Ossie Bluege | 198 | 703 | 1923-1926 | |
| Peaches Graham | 198 | 793 | 1910-1914 | ||
| 98. | Jack Rothrock | 191 | 579 | 1925-1929 | |
| 99. | Herb Thomas | 186 | 515 | 1927-1929 | |
| 100. | Roy Hartzell | 173 | 713 | 1908-1918 |
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