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| Third Basemen Career Runs Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Runs | PA | Years | Single Season Leaderboard |
| 1. | Jim Delahanty * | 1209 | 9038 | 1901-1917 | |
| 2. | Eddie Collins | 1201 | 9111 | 1907-1923 | |
| 3. | Tim Hendryx | 1101 | 9104 | 1914-1929 | |
| 4. | Wid Conroy | 1066 | 8325 | 1901-1915 | |
| 5. | Frank Baker * | 1008 | 7699 | 1908-1922 | |
| 6. | Dutch Zwilling | 953 | 7283 | 1913-1925 | |
| 7. | Joe Tinker | 926 | 7808 | 1902-1916 | |
| 8. | Larry Gardner | 920 | 7641 | 1909-1925 | |
| 9. | Vic Saier | 905 | 7602 | 1911-1928 | |
| 10. | Biz Mackey | 903 | 6500 | 1919-1929 | |
| 11. | Art Devlin | 867 | 6342 | 1904-1915 | |
| 12. | Sammy Strang | 855 | 7165 | 1901-1913 | |
| 13. | John McGraw | 847 | 6436 | 1901-1912 | |
| 14. | Jimmy Esmond | 791 | 6032 | 1914-1926 | |
| 15. | John Beckwith | 755 | 4766 | 1922-1929 | |
| 16. | Bill Coughlin | 752 | 6433 | 1901-1913 | |
| 17. | Oliver Marcelle | 700 | 4972 | 1921-1929 | |
| Otto Krueger | 700 | 6069 | 1901-1912 | ||
| 19. | Jud Wilson | 685 | 4716 | 1922-1929 | |
| 20. | Bill Bradley | 679 | 5187 | 1901-1912 | |
| 21. | Tommy Leach | 658 | 5228 | 1901-1913 | |
| 22. | Clyde Barnhart | 641 | 4619 | 1920-1929 | |
| 23. | Jimmy Johnston | 640 | 5077 | 1914-1924 | |
| 24. | Willie Keeler * | 626 | 4275 | 1901-1908 | |
| 25. | Harry Wolverton | 620 | 4658 | 1901-1909 | |
| 26. | Frank Brazill | 611 | 4408 | 1922-1929 | |
| 27. | Bill Friel | 593 | 4817 | 1901-1912 | |
| 28. | Mike Mowrey | 561 | 5023 | 1905-1919 | |
| 29. | Ray Chapman | 560 | 5110 | 1913-1924 | |
| 30. | Jimmy Collins | 554 | 4116 | 1901-1908 | |
| 31. | Harry Steinfeldt | 538 | 4687 | 1901-1910 | |
| 32. | Howie Shanks | 531 | 4099 | 1914-1928 | |
| 33. | Larry Schlafly | 497 | 4214 | 1903-1913 | |
| 34. | She Donahue | 446 | 4713 | 1905-1915 | |
| 35. | Hank Gowdy | 428 | 4241 | 1914-1923 | |
| 36. | Wally Kimmick | 415 | 3050 | 1920-1929 | |
| 37. | Shano Collins | 406 | 3062 | 1913-1918 | |
| 38. | Lew Drill | 400 | 3649 | 1902-1912 | |
| 39. | Joe Birmingham | 399 | 3923 | 1907-1920 | |
| 40. | Rev Cannady | 390 | 2950 | 1925-1929 | |
| 41. | Doc Prothro | 385 | 2860 | 1920-1928 | |
| 42. | Buck Herzog | 370 | 3349 | 1908-1919 | |
| 43. | Sport McAllister | 354 | 3171 | 1901-1908 | |
| 44. | Dave Malarcher | 353 | 2581 | 1919-1927 | |
| 45. | Bibb Falk | 347 | 2546 | 1920-1926 | |
| 46. | Willie Wells | 342 | 2272 | 1925-1929 | |
| 47. | Fred Raymer | 341 | 3618 | 1901-1913 | |
| 48. | Emil Batch | 338 | 2939 | 1908-1916 | |
| 49. | Doc Casey | 328 | 2341 | 1901-1908 | |
| 50. | Harry Lord | 324 | 2620 | 1908-1914 | |
| 51. | Art Fletcher | 295 | 2784 | 1909-1917 | |
| 52. | John Murphy | 293 | 3441 | 1902-1909 | |
| 53. | Fred Hartman | 291 | 1998 | 1901-1905 | |
| 54. | Tony Boeckel | 284 | 2734 | 1917-1922 | |
| 55. | Frank Ellerbe | 272 | 2472 | 1919-1929 | |
| 56. | Sammy Hale | 252 | 1921 | 1921-1929 | |
| 57. | Grover Hartley | 247 | 2834 | 1913-1922 | |
| 58. | Gene Robertson | 245 | 2054 | 1920-1929 | |
| 59. | Fred Haney | 228 | 1870 | 1922-1929 | |
| 60. | Joe Sargent | 224 | 1601 | 1921-1925 | |
| 61. | Ray Morgan | 210 | 2011 | 1917-1924 | |
| 62. | Mel Ott | 204 | 1775 | 1926-1929 | |
| 63. | John Dobbs | 191 | 1832 | 1901-1907 | |
| 64. | Larry Bettencourt | 173 | 1192 | 1928-1929 | |
| 65. | Fred Jacklitsch | 162 | 1939 | 1901-1909 | |
| 66. | Pep Clark | 155 | 1096 | 1903-1916 | |
| 67. | Alec Radcliffe | 154 | 1416 | 1926-1929 | |
| 68. | Tommy Clarke | 153 | 1483 | 1910-1921 | |
| 69. | Willie Kamm | 147 | 1094 | 1923-1929 | |
| Hughie Critz | 147 | 914 | 1924-1929 | ||
| 71. | Bobby Murray | 146 | 887 | 1923-1928 | |
| 72. | Frank McCue | 142 | 1211 | 1923-1929 | |
| 73. | Judy Johnson | 140 | 1263 | 1921-1928 | |
| 74. | Charlie Dearmond | 136 | 1331 | 1903-1912 | |
| 75. | Jack Thoney | 131 | 1225 | 1906-1912 | |
| Lave Cross | 131 | 1300 | 1901-1904 | ||
| 77. | Jimmy Burke | 123 | 1441 | 1901-1907 | |
| 78. | Newt Joseph | 122 | 882 | 1923-1926 | |
| 79. | Fred Thomas | 115 | 809 | 1920-1924 | |
| Jack Dunn | 115 | 1352 | 1901-1908 | ||
| 81. | Charlie Irwin | 112 | 1114 | 1901-1905 | |
| 82. | Charlie Deal | 108 | 1117 | 1915-1926 | |
| 83. | Fred Merkle | 106 | 1201 | 1912-1921 | |
| 84. | Curt Bernard | 104 | 1243 | 1901-1907 | |
| 85. | Red Smith | 101 | 1074 | 1913-1922 | |
| 86. | Dots Miller | 99 | 1021 | 1909-1920 | |
| 87. | Scotty Ingerton | 98 | 1206 | 1916-1921 | |
| 88. | Andy High | 91 | 914 | 1922-1929 | |
| Phil Geier | 91 | 1026 | 1901-1907 | ||
| 90. | Babe Pinelli | 84 | 837 | 1919-1928 | |
| 91. | Pinky Whitney | 81 | 789 | 1928-1929 | |
| Charlie Pick | 81 | 926 | 1915-1920 | ||
| George Rohe | 81 | 986 | 1901-1908 | ||
| 94. | Heinie Schuble | 76 | 832 | 1927-1928 | |
| 95. | Buck Jordan | 74 | 853 | 1927-1929 | |
| 96. | Germany Schaefer | 73 | 1016 | 1901-1910 | |
| 97. | Baldy Louden | 72 | 814 | 1910-1918 | |
| 98. | Chuck Dressen | 70 | 531 | 1925-1926 | |
| 99. | Harry Spratt | 69 | 739 | 1915-1921 | |
| 100. | Bill McKechnie | 63 | 713 | 1914-1922 |
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