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| Catchers Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Art Wilson | 677 | 3770 | 1908-1923 | |
| 2. | Frank Owens | 647 | 6241 | 1908-1921 | |
| 3. | Bubbles Hargrave | 572 | 5652 | 1914-1927 | |
| 4. | Eddie Ainsmith | 487 | 6083 | 1911-1928 | |
| 5. | Roger Bresnahan | 486 | 8685 | 1901-1916 | |
| 6. | Chief Meyers | 465 | 4628 | 1909-1919 | |
| 7. | Wally Schang | 446 | 4996 | 1913-1925 | |
| 8. | Louis Santop | 431 | 5277 | 1918-1927 | |
| 9. | Pat Collins | 405 | 5169 | 1919-1929 | |
| Jiggs Donahue | 405 | 3968 | 1901-1911 | ||
| 11. | Lena Styles | 343 | 3069 | 1919-1929 | |
| 12. | Jake Stahl | 342 | 5343 | 1905-1915 | |
| Johnny Kling | 342 | 6605 | 1901-1913 | ||
| 14. | Cliff Lee | 340 | 5298 | 1919-1929 | |
| 15. | Nig Clarke | 336 | 3616 | 1907-1918 | |
| 16. | Ed McFarland | 335 | 4994 | 1901-1910 | |
| 17. | Bunny Madden | 316 | 1223 | 1911-1918 | |
| Frank Chance * | 316 | 7755 | 1901-1914 | ||
| 19. | Johnny Schulte | 305 | 2994 | 1924-1929 | |
| 20. | Les Nunamaker | 302 | 2791 | 1913-1924 | |
| 21. | Pinky Hargrave | 287 | 3153 | 1923-1929 | |
| 22. | Joe Sugden | 286 | 3187 | 1901-1907 | |
| 23. | Gabby Hartnett | 282 | 2514 | 1922-1929 | |
| 24. | Tacks Latimer | 263 | 2702 | 1901-1915 | |
| 25. | Gus Fisher | 262 | 2491 | 1914-1922 | |
| 26. | Jack Lapp | 257 | 1988 | 1911-1917 | |
| Jack Zalusky | 257 | 3602 | 1903-1916 | ||
| 28. | Fred Tenney | 237 | 4137 | 1901-1908 | |
| 29. | Ted Easterly | 234 | 5135 | 1909-1919 | |
| 30. | Admiral Schlei | 233 | 1925 | 1905-1911 | |
| 31. | Harry Smith | 231 | 3043 | 1901-1911 | |
| 32. | Red Kleinow | 227 | 3745 | 1906-1913 | |
| 33. | Fred Carisch | 224 | 2240 | 1906-1918 | |
| 34. | Lee Fohl | 218 | 2823 | 1902-1909 | |
| 35. | Fred Hofmann | 213 | 3733 | 1919-1929 | |
| 36. | Boileryard Clarke | 211 | 2727 | 1901-1907 | |
| 37. | Hank Severeid | 206 | 5027 | 1911-1927 | |
| 38. | Jimmy Archer | 201 | 1025 | 1910-1913 | |
| 39. | Frank Bruggy | 197 | 2072 | 1921-1926 | |
| 40. | Ossee Schreckengost | 196 | 2376 | 1901-1909 | |
| 41. | Bernie Hungling | 195 | 2695 | 1922-1929 | |
| 42. | Farmer Steelman | 189 | 3068 | 1901-1909 | |
| 43. | Bill Killefer | 185 | 2633 | 1913-1923 | |
| 44. | Frank Roth | 176 | 3352 | 1903-1913 | |
| 45. | Earl Smith | 174 | 5497 | 1919-1929 | |
| 46. | Billy Sullivan | 173 | 2711 | 1901-1910 | |
| 47. | Jimmie Long | 170 | 2035 | 1923-1929 | |
| 48. | George Gibson | 168 | 2105 | 1908-1914 | |
| Heinie Peitz | 168 | 2143 | 1901-1906 | ||
| 50. | Al Devormer | 165 | 1379 | 1918-1921 | |
| 51. | Bob Wood | 164 | 1237 | 1901-1903 | |
| 52. | Joe McCarthy | 163 | 3182 | 1911-1918 | |
| 53. | Glenn Myatt | 158 | 2393 | 1920-1927 | |
| 54. | Butch Henline | 152 | 1941 | 1921-1929 | |
| Nick Allen | 152 | 724 | 1914-1919 | ||
| Joe Wall | 152 | 2781 | 1901-1908 | ||
| 57. | George Yeager | 151 | 2137 | 1901-1909 | |
| 58. | Truck Hannah | 149 | 1168 | 1918-1923 | |
| 59. | George Stone | 147 | 2686 | 1906-1912 | |
| 60. | Harry Bemis | 145 | 3269 | 1902-1908 | |
| 61. | Tom Leahy | 134 | 1338 | 1901-1904 | |
| 62. | Pete Lapan | 131 | 1115 | 1922-1927 | |
| 63. | Johnny Gooch | 128 | 1475 | 1921-1929 | |
| 64. | Pat Deisel | 124 | 1359 | 1902-1910 | |
| 65. | Bill Carrigan | 122 | 2205 | 1908-1917 | |
| Fred Abbott | 122 | 971 | 1903-1911 | ||
| Red Dooin | 122 | 1733 | 1902-1910 | ||
| 68. | Johnny Bassler | 120 | 6146 | 1914-1929 | |
| 69. | Joe Connor | 118 | 1923 | 1901-1910 | |
| 70. | Tex Erwin | 110 | 793 | 1910-1919 | |
| 71. | John Henry | 106 | 980 | 1916-1920 | |
| 72. | Ed Sweeney | 104 | 1909 | 1911-1919 | |
| 73. | Deacon McGuire | 102 | 970 | 1901-1903 | |
| 74. | Rip Williams | 101 | 678 | 1911-1912 | |
| Lew Ritter | 101 | 1711 | 1902-1909 | ||
| 76. | Val Picinich | 98 | 1421 | 1917-1925 | |
| 77. | Charlie Luskey | 93 | 1170 | 1901-1911 | |
| 78. | Bill Skiff | 92 | 1846 | 1921-1929 | |
| 79. | Duke Farrell | 90 | 862 | 1901-1903 | |
| 80. | Lew McCarty | 89 | 715 | 1916-1919 | |
| 81. | Ed Burns | 86 | 1491 | 1916-1923 | |
| 82. | Doc Kerr | 83 | 353 | 1914-1916 | |
| 83. | Jack Coveney | 81 | 290 | 1904-1905 | |
| 84. | Walt Lerian | 80 | 824 | 1928-1929 | |
| 85. | Bill Perkins | 78 | 990 | 1928-1929 | |
| Ivey Wingo | 78 | 503 | 1917-1922 | ||
| 87. | Bill Rariden | 72 | 716 | 1911-1915 | |
| 88. | Malachi Kittridge | 71 | 834 | 1901-1905 | |
| 89. | Al Lopez | 70 | 902 | 1928-1929 | |
| Mike Kahoe | 70 | 933 | 1901-1906 | ||
| 91. | Jack Ryan | 69 | 661 | 1901-1904 | |
| 92. | Chief Zimmer | 67 | 398 | 1901-1901 | |
| 93. | Billy Maloney | 66 | 895 | 1901-1904 | |
| 94. | Johnny Grabowski | 65 | 887 | 1926-1927 | |
| 95. | Cy Perkins | 63 | 1020 | 1916-1926 | |
| Joe Berry | 63 | 458 | 1902-1907 | ||
| 97. | Buck Crouse | 62 | 2054 | 1923-1929 | |
| 98. | Mickey Cochrane | 57 | 2139 | 1925-1929 | |
| Ira Thomas | 57 | 1411 | 1908-1917 | ||
| Jack Bliss | 57 | 267 | 1908-1910 |
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