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| Catchers Career Runs Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Runs | PA | Years | Single Season Leaderboard |
| 1. | Roger Bresnahan | 1190 | 8685 | 1901-1916 | |
| 2. | Frank Chance * | 1061 | 7755 | 1901-1914 | |
| 3. | Louis Santop | 779 | 5277 | 1918-1927 | |
| 4. | Johnny Bassler | 759 | 6146 | 1914-1929 | |
| 5. | Johnny Kling | 741 | 6605 | 1901-1913 | |
| 6. | Earl Smith | 732 | 5497 | 1919-1929 | |
| 7. | Cliff Lee | 666 | 5298 | 1919-1929 | |
| 8. | Ed McFarland | 662 | 4994 | 1901-1910 | |
| 9. | Eddie Ainsmith | 661 | 6083 | 1911-1928 | |
| 10. | Bubbles Hargrave | 655 | 5652 | 1914-1927 | |
| 11. | Frank Owens | 647 | 6241 | 1908-1921 | |
| 12. | Pat Collins | 614 | 5169 | 1919-1929 | |
| 13. | Wally Schang | 613 | 4996 | 1913-1925 | |
| 14. | Jake Stahl | 597 | 5343 | 1905-1915 | |
| 15. | Hank Severeid | 560 | 5027 | 1911-1927 | |
| 16. | Chief Meyers | 542 | 4628 | 1909-1919 | |
| 17. | Ted Easterly | 517 | 5135 | 1909-1919 | |
| 18. | Fred Tenney | 476 | 4137 | 1901-1908 | |
| 19. | Fred Hofmann | 429 | 3733 | 1919-1929 | |
| 20. | Johnny Schulte | 417 | 2994 | 1924-1929 | |
| 21. | Jiggs Donahue | 400 | 3968 | 1901-1911 | |
| 22. | Lena Styles | 380 | 3069 | 1919-1929 | |
| 23. | Bernie Hungling | 379 | 2695 | 1922-1929 | |
| 24. | Harry Bemis | 376 | 3269 | 1902-1908 | |
| 25. | Pinky Hargrave | 362 | 3153 | 1923-1929 | |
| 26. | Frank Roth | 352 | 3352 | 1903-1913 | |
| 27. | Art Wilson | 338 | 3770 | 1908-1923 | |
| 28. | Bob O'Farrell | 328 | 3032 | 1919-1929 | |
| 29. | Nig Clarke | 322 | 3616 | 1907-1918 | |
| 30. | Joe McCarthy | 316 | 3182 | 1911-1918 | |
| 31. | Glenn Myatt | 312 | 2393 | 1920-1927 | |
| 32. | Jack Zalusky | 310 | 3602 | 1903-1916 | |
| 33. | Gus Fisher | 296 | 2491 | 1914-1922 | |
| 34. | George Stone | 293 | 2686 | 1906-1912 | |
| 35. | Boileryard Clarke | 291 | 2727 | 1901-1907 | |
| 36. | Les Nunamaker | 282 | 2791 | 1913-1924 | |
| 37. | Harry Smith | 278 | 3043 | 1901-1911 | |
| 38. | Joe Sugden | 271 | 3187 | 1901-1907 | |
| 39. | Red Kleinow | 266 | 3745 | 1906-1913 | |
| 40. | Gabby Hartnett | 263 | 2514 | 1922-1929 | |
| 41. | Joe Wall | 261 | 2781 | 1901-1908 | |
| 42. | Farmer Steelman | 254 | 3068 | 1901-1909 | |
| 43. | Heinie Peitz | 252 | 2143 | 1901-1906 | |
| 44. | Billy Sullivan | 251 | 2711 | 1901-1910 | |
| 45. | Frank Bruggy | 245 | 2072 | 1921-1926 | |
| 46. | Mickey Cochrane | 243 | 2139 | 1925-1929 | |
| 47. | Buck Crouse | 242 | 2054 | 1923-1929 | |
| 48. | Jimmie Long | 240 | 2035 | 1923-1929 | |
| 49. | Bill Killefer | 236 | 2633 | 1913-1923 | |
| 50. | Ossee Schreckengost | 234 | 2376 | 1901-1909 | |
| 51. | Lee Fohl | 233 | 2823 | 1902-1909 | |
| 52. | George Yeager | 232 | 2137 | 1901-1909 | |
| 53. | Bill Carrigan | 226 | 2205 | 1908-1917 | |
| 54. | Butch Henline | 215 | 1941 | 1921-1929 | |
| 55. | Bill Skiff | 213 | 1846 | 1921-1929 | |
| 56. | Jack Lapp | 198 | 1988 | 1911-1917 | |
| 57. | George Gibson | 187 | 2105 | 1908-1914 | |
| 58. | Johnny Gooch | 181 | 1475 | 1921-1929 | |
| 59. | Tacks Latimer | 180 | 2702 | 1901-1915 | |
| 60. | Joe Connor | 179 | 1923 | 1901-1910 | |
| 61. | Luke Sewell | 163 | 1481 | 1925-1929 | |
| 62. | Admiral Schlei | 162 | 1925 | 1905-1911 | |
| 63. | Bennie Tate | 158 | 1456 | 1924-1929 | |
| 64. | Ed Sweeney | 157 | 1909 | 1911-1919 | |
| 65. | Fred Carisch | 156 | 2240 | 1906-1918 | |
| 66. | Ira Thomas | 146 | 1411 | 1908-1917 | |
| 67. | Val Picinich | 145 | 1421 | 1917-1925 | |
| 68. | John Warner | 144 | 1503 | 1901-1906 | |
| 69. | Red Dooin | 136 | 1733 | 1902-1910 | |
| 70. | Ed Burns | 132 | 1491 | 1916-1923 | |
| 71. | Al Devormer | 128 | 1379 | 1918-1921 | |
| Bob Wood | 128 | 1237 | 1901-1903 | ||
| 73. | Tom Leahy | 123 | 1338 | 1901-1904 | |
| 74. | Lew Ritter | 116 | 1711 | 1902-1909 | |
| 75. | Bill Perkins | 115 | 990 | 1928-1929 | |
| Muddy Ruel | 115 | 1023 | 1920-1928 | ||
| Pete Lapan | 115 | 1115 | 1922-1927 | ||
| 78. | Truck Hannah | 111 | 1168 | 1918-1923 | |
| Billy Maloney | 111 | 895 | 1901-1904 | ||
| 80. | Pat Deisel | 110 | 1359 | 1902-1910 | |
| 81. | Charlie Luskey | 103 | 1170 | 1901-1911 | |
| 82. | Tom Needham | 98 | 1092 | 1906-1912 | |
| 83. | Malachi Kittridge | 95 | 834 | 1901-1905 | |
| 84. | Bill Dickey | 93 | 822 | 1928-1929 | |
| Deacon McGuire | 93 | 970 | 1901-1903 | ||
| 86. | Walt Lerian | 92 | 824 | 1928-1929 | |
| 87. | Duke Farrell | 91 | 862 | 1901-1903 | |
| 88. | Jimmie Wilson | 89 | 820 | 1923-1929 | |
| 89. | Al Lopez | 83 | 902 | 1928-1929 | |
| 90. | John Henry | 82 | 980 | 1916-1920 | |
| Pete Noonan | 82 | 893 | 1910-1918 | ||
| Lou Criger | 82 | 715 | 1901-1904 | ||
| 93. | Johnny Grabowski | 81 | 887 | 1926-1927 | |
| Cy Perkins | 81 | 1020 | 1916-1926 | ||
| 95. | Harry McCurdy | 80 | 638 | 1925-1928 | |
| 96. | Tex Erwin | 79 | 793 | 1910-1919 | |
| Fred Abbott | 79 | 971 | 1903-1911 | ||
| 98. | Jack Cummings | 77 | 653 | 1928-1929 | |
| Mike Kahoe | 77 | 933 | 1901-1906 | ||
| 100. | Rollie Hemsley | 74 | 619 | 1928-1929 |
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