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| Single-Season Runs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Runs | PA | Year | Career Leaderboard |
| 1. | Babe Ruth | 151 | 672 | 1925 | |
| Joe Jackson | 151 | 697 | 1911 | ||
| 3. | Joe Jackson | 141 | 681 | 1914 | |
| 4. | Joe Jackson | 137 | 659 | 1912 | |
| 5. | Joe Jackson | 136 | 662 | 1916 | |
| 6. | Honus Wagner * | 135 | 682 | 1905 | |
| Roy Thomas | 135 | 634 | 1903 | ||
| 8. | Chino Smith | 133 | 673 | 1924 | |
| 9. | Kid Elberfeld | 132 | 615 | 1903 | |
| 10. | Elmer Flick * | 131 | 679 | 1904 | |
| 11. | Babe Ruth | 129 | 625 | 1921 | |
| Oscar Charleston | 129 | 627 | 1920 | ||
| 13. | Turkey Stearnes | 126 | 659 | 1925 | |
| Babe Ruth | 126 | 644 | 1924 | ||
| Mike Donlin * | 126 | 647 | 1905 | ||
| Roy Thomas | 126 | 594 | 1902 | ||
| 17. | Jimmy Williams * | 125 | 679 | 1911 | |
| Homer Smoot * | 125 | 621 | 1905 | ||
| Jimmy Williams * | 125 | 645 | 1904 | ||
| 20. | Chino Smith | 124 | 660 | 1926 | |
| Oscar Charleston | 124 | 669 | 1925 | ||
| John Beckwith | 124 | 632 | 1923 | ||
| Joe Jackson | 124 | 637 | 1918 | ||
| Ed Delahanty * | 124 | 609 | 1902 | ||
| 25. | Joe Jackson | 123 | 662 | 1913 | |
| Jimmy Williams * | 123 | 645 | 1905 | ||
| Ed Delahanty * | 123 | 602 | 1901 | ||
| 28. | Claude Ritchey | 122 | 672 | 1904 | |
| 29. | Homer Smoot * | 121 | 721 | 1911 | |
| Jimmy Williams * | 121 | 630 | 1908 | ||
| 31. | Lou Gehrig | 120 | 637 | 1925 | |
| Sam Crawford * | 120 | 688 | 1911 | ||
| Cy Seymour | 120 | 614 | 1905 | ||
| 34. | Patsy Dougherty | 119 | 643 | 1904 | |
| Jimmy Collins | 119 | 620 | 1901 | ||
| 36. | Jim Bottomley | 118 | 652 | 1924 | |
| Oscar Charleston | 118 | 638 | 1922 | ||
| Ty Cobb * | 118 | 666 | 1911 | ||
| Harry Davis | 118 | 680 | 1905 | ||
| Sam Crawford * | 118 | 650 | 1905 | ||
| Bill Keister | 118 | 648 | 1904 | ||
| Fred Clarke | 118 | 574 | 1903 | ||
| 43. | Chino Smith | 117 | 673 | 1925 | |
| Babe Ruth | 117 | 645 | 1923 | ||
| Elmer Smith | 117 | 663 | 1922 | ||
| Dobie Moore | 117 | 653 | 1920 | ||
| Homer Smoot * | 117 | 694 | 1912 | ||
| Ty Cobb * | 117 | 679 | 1908 | ||
| Harry Davis | 117 | 647 | 1904 | ||
| 50. | Bucky Harris | 116 | 631 | 1921 | |
| Josh Devore | 116 | 671 | 1914 | ||
| Jimmy Sheckard * | 116 | 640 | 1904 | ||
| Bill Dahlen | 116 | 591 | 1904 | ||
| 54. | Rogers Hornsby | 115 | 667 | 1927 | |
| Frank Brazill | 115 | 644 | 1923 | ||
| Dobie Moore | 115 | 604 | 1923 | ||
| Amby McConnell | 115 | 659 | 1916 | ||
| 58. | Sam Rice | 114 | 659 | 1922 | |
| George Sisler | 114 | 655 | 1922 | ||
| Benny Kauff | 114 | 648 | 1921 | ||
| George Burns | 114 | 663 | 1916 | ||
| Eddie Collins | 114 | 658 | 1916 | ||
| Jimmy Barrett | 114 | 688 | 1907 | ||
| John McGraw | 114 | 615 | 1903 | ||
| Sam Crawford * | 114 | 573 | 1902 | ||
| 66. | Oscar Charleston | 113 | 641 | 1924 | |
| Lou Gehrig | 113 | 584 | 1924 | ||
| Rogers Hornsby | 113 | 663 | 1923 | ||
| Jimmy Johnston | 113 | 629 | 1921 | ||
| Patsy Dougherty | 113 | 653 | 1906 | ||
| Joe Kelley | 113 | 657 | 1904 | ||
| Elmer Flick * | 113 | 628 | 1903 | ||
| 73. | Lou Gehrig | 112 | 668 | 1927 | |
| George Sisler | 112 | 654 | 1925 | ||
| George Carr | 112 | 675 | 1923 | ||
| Bob Meusel | 112 | 589 | 1921 | ||
| Rogers Hornsby | 112 | 606 | 1920 | ||
| John Anderson | 112 | 602 | 1903 | ||
| Jimmy Barrett | 112 | 600 | 1903 | ||
| 80. | Dutch Zwilling | 111 | 627 | 1922 | |
| Oscar Charleston | 111 | 629 | 1921 | ||
| Chick Gandil | 111 | 532 | 1921 | ||
| Joe Jackson | 111 | 668 | 1917 | ||
| Zack Wheat * | 111 | 643 | 1917 | ||
| Zack Wheat * | 111 | 661 | 1916 | ||
| Ginger Beaumont * | 111 | 659 | 1912 | ||
| Sam Crawford * | 111 | 656 | 1909 | ||
| Elmer Flick * | 111 | 638 | 1905 | ||
| Jimmy Slagle | 111 | 651 | 1904 | ||
| Dave Fultz | 111 | 626 | 1903 | ||
| 91. | Jelly Gardner | 110 | 512 | 1927 | |
| John Beckwith | 110 | 618 | 1924 | ||
| Dick Lundy | 110 | 638 | 1923 | ||
| Dick Lundy | 110 | 670 | 1922 | ||
| Wid Conroy | 110 | 690 | 1905 | ||
| Billy Gilbert | 110 | 659 | 1905 | ||
| Ginger Beaumont * | 110 | 651 | 1904 | ||
| Jesse Burkett | 110 | 593 | 1903 | ||
| Jimmy Williams * | 110 | 595 | 1901 | ||
| 100. | Kiki Cuyler | 109 | 620 | 1926 |
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