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| Single-Season Hits Allowed Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Hits Allowed | IP | Year | Career Leaderboard |
| 1. | Heinie Meine | 426 | 338.7 | 1928 | |
| 2. | Bob Hasty | 421 | 333.0 | 1927 | |
| 3. | Jim Bagby | 419 | 323.7 | 1921 | |
| 4. | Jesse Barnes | 418 | 346.3 | 1923 | |
| 5. | Jesse Tannehill * | 416 | 401.7 | 1904 | |
| 6. | Hooks Dauss | 415 | 340.0 | 1920 | |
| Chief Bender | 415 | 382.0 | 1904 | ||
| 8. | Rube Kroh | 413 | 311.0 | 1921 | |
| 9. | Jesse Stovall | 411 | 357.3 | 1904 | |
| 10. | Jesse Tannehill * | 408 | 378.3 | 1906 | |
| 11. | Jesse Barnes | 407 | 343.7 | 1920 | |
| 12. | Hooks Dauss | 405 | 357.3 | 1922 | |
| Rube Vickers * | 405 | 356.3 | 1914 | ||
| Ed Killian | 405 | 364.3 | 1904 | ||
| 15. | Chief Yellowhorse | 404 | 325.3 | 1927 | |
| 16. | Jesse Barnes | 403 | 348.3 | 1927 | |
| Sam McMackin | 403 | 356.0 | 1904 | ||
| 18. | Rube Foster | 402 | 321.7 | 1913 | |
| 19. | Andy Cooper | 401 | 308.3 | 1927 | |
| 20. | Jesse Barnes | 400 | 341.3 | 1928 | |
| Ed Killian | 400 | 385.3 | 1905 | ||
| 22. | Jim Bagby | 399 | 362.3 | 1917 | |
| 23. | Bob Dresser | 397 | 362.7 | 1911 | |
| 24. | Roscoe Miller | 396 | 397.7 | 1904 | |
| 25. | Joe Shaute | 395 | 344.0 | 1925 | |
| Cy Vorhees | 395 | 348.0 | 1904 | ||
| Sam Leever | 395 | 383.3 | 1902 | ||
| 28. | Jesse Barnes | 392 | 333.3 | 1922 | |
| Alex Hardy | 392 | 380.0 | 1905 | ||
| 30. | Bill Holland | 391 | 331.7 | 1926 | |
| 31. | Claude Davenport | 390 | 322.3 | 1929 | |
| Red Causey | 390 | 311.7 | 1927 | ||
| Jesse Haines | 390 | 351.3 | 1922 | ||
| 34. | Chief Yellowhorse | 389 | 330.7 | 1921 | |
| Ralph Caldwell * | 389 | 347.7 | 1920 | ||
| 36. | Jesse Haines | 388 | 345.0 | 1920 | |
| Charley Hall | 388 | 342.0 | 1920 | ||
| Rube Vickers * | 388 | 371.3 | 1913 | ||
| 39. | John Burke | 387 | 361.7 | 1904 | |
| Bill Dineen | 387 | 339.0 | 1901 | ||
| 41. | John Donaldson | 386 | 334.3 | 1925 | |
| 42. | Irv Higginbotham | 385 | 278.3 | 1916 | |
| 43. | Jake Northrop | 384 | 281.7 | 1921 | |
| 44. | Bill Holland | 383 | 334.7 | 1925 | |
| 45. | Ed Siever | 381 | 361.0 | 1904 | |
| Vic Willis | 381 | 346.0 | 1902 | ||
| 47. | Ham Iburg | 380 | 366.7 | 1906 | |
| 48. | Jesse Barnes | 379 | 308.7 | 1919 | |
| Rube Vickers * | 379 | 368.0 | 1912 | ||
| Barney Wolfe | 379 | 357.3 | 1904 | ||
| 51. | Bob Hasty | 378 | 329.3 | 1926 | |
| Ralph Comstock | 378 | 318.3 | 1925 | ||
| Jesse Haines | 378 | 269.7 | 1924 | ||
| Heinie Meine | 378 | 354.0 | 1923 | ||
| Ray Caldwell | 378 | 318.7 | 1922 | ||
| Bob Shawkey | 378 | 350.3 | 1914 | ||
| 57. | Harry Courtney | 377 | 304.3 | 1927 | |
| Christy Mathewson | 377 | 372.0 | 1914 | ||
| Tom Walker | 377 | 355.0 | 1911 | ||
| John Burke | 377 | 374.0 | 1905 | ||
| 61. | Chet Brewer | 376 | 327.7 | 1925 | |
| Pat Ragan | 376 | 332.0 | 1912 | ||
| John Burke | 376 | 371.0 | 1906 | ||
| Gus Thompson | 376 | 373.0 | 1904 | ||
| 65. | Hod Eller | 375 | 331.3 | 1927 | |
| Claude Hendrix | 375 | 346.3 | 1922 | ||
| Jim Bagby | 375 | 327.7 | 1920 | ||
| Hi West | 375 | 349.0 | 1912 | ||
| Cy Vorhees | 375 | 337.3 | 1907 | ||
| 70. | Hod Eller | 374 | 324.3 | 1929 | |
| Jesse Barnes | 374 | 300.3 | 1921 | ||
| 72. | Red Causey | 373 | 282.7 | 1929 | |
| Ralph Caldwell * | 373 | 333.0 | 1921 | ||
| Barney Wolfe | 373 | 330.0 | 1903 | ||
| 75. | Red Causey | 372 | 320.0 | 1928 | |
| Eddie Rommel | 372 | 322.7 | 1923 | ||
| Jake Boultes | 372 | 364.0 | 1911 | ||
| Jim Buchanan | 372 | 330.7 | 1905 | ||
| 79. | Pete Alexander | 371 | 290.7 | 1921 | |
| Irv Young | 371 | 360.3 | 1906 | ||
| 81. | Sam Leever | 370 | 348.0 | 1906 | |
| War Sanders | 370 | 331.0 | 1904 | ||
| 83. | John Donaldson | 369 | 349.3 | 1922 | |
| Tom Rogers | 369 | 328.0 | 1920 | ||
| Big Jeff Pfeffer | 369 | 370.7 | 1910 | ||
| 86. | Ramon Bragana | 368 | 293.0 | 1929 | |
| Roy Wilkinson | 368 | 316.7 | 1925 | ||
| Ray Caldwell | 368 | 353.3 | 1920 | ||
| Rip Vowinkel * | 368 | 367.0 | 1912 | ||
| Ed Killian | 368 | 337.0 | 1906 | ||
| 91. | Rube Foster | 367 | 332.3 | 1923 | |
| Hooks Dauss | 367 | 322.7 | 1921 | ||
| Jesse Tannehill * | 367 | 388.3 | 1905 | ||
| 94. | Jim Lyle | 366 | 348.0 | 1926 | |
| Joe Shaute | 366 | 318.0 | 1924 | ||
| Guy Morton | 366 | 317.0 | 1923 | ||
| Jack Taylor | 366 | 326.7 | 1901 | ||
| 98. | Rube Kroh | 365 | 355.3 | 1920 | |
| Rube Kroh | 365 | 322.0 | 1919 | ||
| Chief Bender | 365 | 366.0 | 1918 |
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